The current development in technology, infrastructure, telecommunication, medicine, agriculture, economic and social aspects of human life owe to the hard work of bunch of researchers, scientists and innovators. The key pillar contributing to the entire progress and facilitation enjoyed by humankind is undoubtedly new knowledge which has been created on the basis of endeavors in society, class rooms and laboratories. The study of unfamiliar human skills 2.5 million years ago and known advances made during medieval to early modern, industrial and IT revolution ages points that we are on the verge of a new paradigm. The humanity is facing threats related to energy, economy, security, water, climate, peace and a growing division on variety of basis. The upcoming challenges demand integrated global efforts because any disaster will not be affordable and limited to a certain region of the world. The paradigm shift has become essential and only that research is worthwhile which is carried out to solve the problems. The expectations from the academicians, technologists, scientists, innovators and leaders are on the peak.